DDP 2010: Technology Showcase Spotlight Session - Explore the P.L.E.A.S.E. (Painless Laser Epidermal System) Progress on Laser-Based Epidermal Protein

Christof Boehler, PhD
Chief Executive Officer
Pantec Biosolutions AG

The target component to address in this case is the epidermis. The hand held device creates the micro-pores. They can control the accurate array of micro-pores. It’s without pain and causes small amounts of damage. It is independent of the skin condition.

Regulatory and intellectual property estate. One product: IVF001, IVF002, both for infertility. They can get the protein across the skin at therapeutic levels. The protein can be delivered from the patch at therapeutic concentrations.

The delivery of vaccines – application of ovalbumin using P.L.E.A.S.E. ® lead to activation of APCs. The immunization with recombinant proteins using please is superior to interdermal needle injection.

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New Bubble Gum Type Adhesive For Enhancing Drug Delivery in the Stomach

This article in Science Daily discusses how the reason why insulin can not be swallowed is because it doesn't survive the trip through the digestive tract, and because of this Tejal A. Desai from the University of California is looking to design new ways to deliver drugs orally that would help their absorption in the gut.

Tejal, working closely with a Bay-area biotechnology company, has designed devices that resemble spiny beads filled with drugs. The spines on the beads are filled with silicon and are designed to form an adhesive that covers the cell lining in the gut. This way, the drugs have a better shot of diffusing into the bloodstream. Tejal Desai will present shortly in her findings, what other methods of oral drug delivery will we see in the future?

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Should the FDA be allowed to regulate e-cigarettes?

The LA Times looks at the current debate over e-cigarettes. This device allows smokers to get their nicotine fix through a small, smokeless electronic cigarette shaped device. The US FDA believes that they should be able to regulate them, as it can prove as a new gateway device to target teenagers who could be turned on to cigarettes by their use.

What do you think about this drug deliver device? While it may help millions stop smoking, it may introduce millions more to a new way of consuming nicotine. There are other things, such as lollypops, that contain nicotine, that are not regulated by the FDA, so why should this smoke-free device face FDA regulation?

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New Drug Delivery System Uses Magnetism to Release Medication

This article in Cnet highlights an effective new approach to delivering intermittent doses of medication that can not be taken orally. Research led by Daniel Kohane at Children's Hospital Boston has uncovered a tiny implantable device that releases the medication through a membrane by switching on an off a magnetic field.

This is a novel approach to delivering drugs and hopefully we should see this come to hospitals soon. What are some other examples of innovative drug delivery systems that are being researched?

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Self-administration drug delivery evolving the industry

According to zikkir, the future of drug delivery is increasingly turning towards self-administration. With medical advances, patients are increasingly able to give themselves their prescriptions. Because these devices that are already pre-filled and easier to use, they're leading to more patient compliance. Read more about the increase in self-administration drug delivery devices here.

What do you think? With the growing number of patient-administered drug delivery devices, do you think this will contribute to a patient's compliance to continually and regularly take their medication?


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