Monday, September 15, 2014

Challenges of analytics for complex molecules versus monoclonal antibodies

Dr. Johnson Varghese, the Senior Director and Head of Analytical Development Group at Shire
Pharmaceuticals, recently sat down with the BioProcess International team to discuss establishing criticality of product attributes, challenge are analytics for complex molecules than for monoclonal antibodies and more.

In the interview, he also looks at in-vitro assays that are being developed using biological materials of fibroblast cells with a physiological relevance. Advantages of this method, which is using cells from patients with the disease  and using relevant sub-sprays include assurance of accurate measuring and it allows you to be able to probe conformational aspects of the enzyme.

Dr. Varghese will be the chair of the Analytical and Quality track at the BioProcess International Conference and Exhibition on Wednesday, October 22.  He will be facilitating presentations around the topics of Elucidating the Structure/Function Relationships of Complex Glycoproteins, Elucidating the Structure/Function Relationships of Complex Glycoproteins and facilitating a panel with the speakers of the day's presentations.  For more information on these sessions and the rest of the program, download the agenda.  As a reader of this blog, when you register to join Dr. Varghese at BioProcess International with code BPI14BLOG, you can save 20% off the standard rate.

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