BioProcess International Poster Preview: Assessment Of Process Performance And Product Quality In High Performing Fed-Batch Cultures

Leading up to the BioProcess International Event, we'll be highlighting many of the posters you'll be able to find in the hall at the event taking place September 16-19, 2013 in Boston, MA. If you'd like to join us at the event, as a reader of this blog, when you register to join us and mention code BLOG13JP, you'll save 20% off the standard rate!

Poster: Assessment Of Process Performance And Product Quality In High Performing Fed-Batch Cultures

Presenter: Thomas Falkman; GE Healthcare

About: Higher yields, more potent compounds, smaller batch sizes and the cost pressure on R&D budgets push the production of biopharmaceuticals towards single-use bioreactors. Simple cultivation systems can be an attractive platform for the production of e.g. monoclonal antibodies by high cell density fed-batch processes. We have developed a high cell density fed-batch process based on an IgG1 producing CHO cell line and the ActiCHO Media System platform in stirred tank bioreactors as well as in WAVE Bioreactor system. Furthermore, the product quality for key product quality attributes, i.e. glycan distribution, molecular size distribution and charge heterogeneity was analyzed.

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