Wednesday, August 28, 2013

BioProcess International Poster Preview: Near-universal Similarity Bounds for Bioassays

Leading up to the BioProcess International Event, we'll be highlighting many of the posters you'll be able to find in the hall at the event taking place September 16-19, 2013 in Boston, MA. If you'd like to join us at the event, as a reader of this blog, when you register to join us and mention code BLOG13JP, you'll save 20% off the standard rate!

Poster: Near-universal Similarity Bounds for Bioassays

Presenter: David Lansky, Precision Bioassay, Inc

About: Several versions of composite and parameter-specific measures of non-similarity will be described and compared. Two approaches to sensitivity analyses yield new ways to examine the potential impact of various amounts of non-similarity and offer a good rationale for universal similarity equivalence acceptance limits. Factorial combinations of various amounts of parametric non-similarity are used in simulations to compare different candidate measures of non-similarity. Comparisons include the properties of each measure of non-similarity (i.e.; bias) and the performance of potency (i.e.; bias). A recommended modification of parameter-specific equivalence bounds for non-similarity yields nearly universally applicable good control of important non-similarity.

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