Poster: Near-universal Similarity Bounds for Bioassays
Presenter: David Lansky, Precision Bioassay, Inc
About: Several versions of composite and parameter-specific measures of non-similarity will be described and compared. Two approaches to sensitivity analyses yield new ways to examine the potential impact of various amounts of non-similarity and offer a good rationale for universal similarity equivalence acceptance limits. Factorial combinations of various amounts of parametric non-similarity are used in simulations to compare different candidate measures of non-similarity. Comparisons include the properties of each measure of non-similarity (i.e.; bias) and the performance of potency (i.e.; bias). A recommended modification of parameter-specific equivalence bounds for non-similarity yields nearly universally applicable good control of important non-similarity.
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