Showing posts with label American Society of Clinical Oncology. Show all posts
Showing posts with label American Society of Clinical Oncology. Show all posts

Friday, June 12, 2015

This Week in BioPharma: 6/8-6/12

Top news from the biopharmaceutical industry this week:

In the future, treatments tailored to patients: Cambridge biotechs such as Genzyme Corp. and Alnylam Pharmaceuticals Inc. are developing personalized treatments for rare genetic disorders like Gaucher and Fabry disease. Vertex Pharmaceuticals Inc. of Boston is turning out a portfolio of medicines that attack the life-threatening lung disease cystic fibrosis by targeting specific genetic mutations.

Getting to the red zone in biopharma R&D: For some time after the FDA put its new breakthrough therapy designation together for the industry, there was a good deal of back and forth among industry analysts over whether the BTD would make much of a difference. You don't hear much of that kind of carping much these days, and a new report from EP Vantage illustrates why.

Study: biopharma innovation outpaces tech overall: Innovation in the biotech and pharmaceutical industries outpaced the combined activity of 12 technology sectors between 2009 and last year, according to a report released today by Thomson Reuters.

The 25 most influential people in biopharma in 2015: A lot of people make news in the biopharma business. Few of them are influential. Influence, simply put, is the ability to make your mark in such a way as to get other prominent people in this business to rethink the way they do business.

Alder Biopharmaceuticals' new drug promises migraine relief:  Shares of clinical-stage biopharmaceutical company Alder Biopharmaceuticals Inc. are up more than 100 percent from the lows they made in late April this year and are currently trading near their all-time highs.One of the main reasons for this surge has been the promising data released by company last month for its migraine treatment drug.

Cancer clinical trials expert to assist Regen BioPharma, Inc. in addressing FDA questions: The goals  of the collaboration is to  address  questions  posed by the FDA regarding  Regn BioPharma, Inc.'s planned  Phase I/II clinical trial assessing safety with signals of efficacy of the dCellVax gene silenced dendritic cell immunotherapy for treating breast cancer and to modify the existing Investigational New Drug application in order to maximize the probability  of clinical trial success.

Merck Millipore develops compaction technology for biopharma: Merck Millipore, the life science business of Germany-based Merck, has developed a new technology that compacts dry powder cell culture media into granules, accelerating solubility and improving flowability and handling. The compacted media are, therefore, more convenient to use, allowing biopharmaceutical manufacturers to further optimize their upstream processes.


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Wednesday, June 3, 2015

Researchers Find New Drugs to Help Fight Cancer

We're looking at another weapon in the arsenal”

A study recent found that a combination of two drugs that helped allow the immune system to fight the cancer -- ipilimumab and nivolumab -- stopped the deadly skin cancer melanoma from advancing for nearly a year in 58 percent of the cases.  

In addition, there are other studies that have shown promise in treating lung cancer, according to CNN. Those involved in the fight against cancer are divided as to just how excited to get over the promise of immunotherapy in battling cancer.

"Immunotherapy drugs have already revolutionized melanoma treatment, and now we're seeing how they might be even more powerful when they're combined," said Dr. Steven O'Day, an expert with the American Society of Clinical Oncology.


"But the results also warrant caution -- the nivolumab and ipilimumab combination used in this study came with greater side effects, which might offset its benefits for some patients. Physicians and patients will need to weigh these considerations carefully," O'Day explained to CNN.

In the study, 36 percent of the patients receiving the two-drug combination had to stop the therapy due to side effects.  Nell Barrie, a spokeswoman for Cancer Research UK, while calling the results "encouraging" and "promising," told CNN that a lot remains to be learned and the new drugs would not replace any of the existing cancer treatments.

According to Barrie, surgery and chemotherapy or radiotherapy would still be vital. Researchers had yet to study the long-term survival rates for immunotherapy, and the side effects can include inflammation of the stomach and bowel serious enough to require hospitalization, said Barrie.
But Dr. James Larkin, the lead author of the melanoma study, called the results a ‘game changer.’ 

"We've seen these drugs working in a wide range of cancers, and I think we are at the beginning of a new era in treating cancer.”


Barrie said immunotherapy could offer hope to people with cancers that are otherwise difficult to treat. "We're looking at another weapon in the arsenal,” he said. 


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