Tuesday, September 1, 2015

Top Scientists Address Downstream Processing

Characterization of Host-Cell Proteins Using Mass Spectrometry Enables Effective Purification Optimization

Lin Zang, Senior Scientist, Analytical Development, Biogen describes the mass spectrometry workflow for host cell protein identification that she will be presenting on at the BioProcess International Conference & Exposition, and discusses the implications of HCPs on downstream process development.

Hear more from Lin at 4:00 pm on Wednesday, October 28, 2015 at BPI.

Listen to her interview here: http://bit.ly/1VucXxR

A Novel Approach to Monitor Clearance of Host Cell Proteins Associated with Monoclonal Antibodies 

The big challenge in downstream process development concerning host cell proteins is that the amount of HCPs in the purified product is often so low that it is hard to determine the identity of the HCP. Min Zhu, Senior Scientist, Purification Process Sciences, MedImmune LLC, describes how the approach she will be presenting at the conference overcomes this challenge.

Hear more from Min at 4:30 pm on Wednesday, October 28, 2015 at BPI.

Listen to her interview here: http://bit.ly/1VucXxR

Implementing Multi-Attribute LC/MS Methods for More Informed Process Development 

Matthew Traylor, Analytical Scientist, Process Development, Shire, discusses how he gets a deep characterization a specific protein out of a mixture, using LC/MS software packages that automate the process. He shares how this technology can be used at laboratory, pilot and production scale process development.

Hear more from Matthew at 9:20 am on Tuesday, October 27, 2015 at BPI.

Listen to his interview here: http://bit.ly/1NKYZWY

Continued Process Verification (CPV) Informatics Systems and Validation 

Carly Cox, Senior Process Engineer, Pfizer, describes what a CPV informatics system is and how it’s used in product manufacturing. She’ll be presenting at the BioProcess International Conference on how multiple source systems can pull data on product manufacturing processing and be collected into a CPV informatics system, and some of the important areas to consider for validation and configuration for regulatory reporting and process monitoring.  

Hear more from Carly at 9:20 am on Wednesday, October 28, 2015 at BPI.

Rapid Microbiological Methods for Real-Time Release of Autologous Cell Therapy Products 

Hear about how a risk based approach to autologous cell therapy products used at Vericel. In this podcast, John Duguid, Principal Scientist, Vericel Corporation, describes how rapid microbiological methods are used in product release of autologous cell therapy products, and discusses the areas of contamination risk. Audio Player

Hear more from John at 2:00 pm on Thursday, October 29, 2015 at BPI.

Listen to his interview here: http://bit.ly/1IFdZ0I

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