According to Jon Rowley, CEO of RoosterBio and Conference Chair of IBC's Cell Therapy Bioprocessing conference, this coming decade will see the
incorporation of living cells into platforms such as engineered tissues, bio-robotics
and implantable devices as well as others not yet imagined. Rowley, a leading expert in this field, will be
discussing the integration of biologics into a series of products at this year’s
Cell
Therapy Bioprocessing conference, September 15-16. Jon has more to offer on the subject in the meantime
and was recently able to weigh in on some of these innovations:
What are some of the
most important cell therapy manufacturing innovations that you’ve seen over the
last few years?
There have been many important advancements that have been
highlighted and presented right here at the Cell Therapy Bioprocessing conference
over the last few years. We are in a very interesting time in the field of cell
therapy where, over the last 10-15 years, we’ve developed some very interesting
product innovations that have shown a very good signal in the clinic.
Now, our field has kind of transitioned into an era of
manufacturing process innovation. We are seeing a very rapid pace of
advancements in manufacturing technologies. I think the advancements fit into
two different classes. The scale-up of the cell culture and then the downstream
processing, which are both equally important. I think that hands down the
conversion to scalable bioreactor expansion methods for allogeneic therapies
will be the most impactful on the field as these technologies allow for
companies to both scale their bioprocess to commercially relevant lot sizes, as
well as help to reduce overall cost of goods.
Also, the field has learned from the traditional protein
biologic field and is attempting to proactively address downstream processing
bottlenecks before they occur. We’ve seen advancements in continuous
centrifugation, like the Ksep technology that will enable the volume reduction,
washing of extremely large volumes of primary cells. This is critical as the
field moves to these large-scale bioreactor processes.
Download the brochure to check out the
rest of Jon Rowley’s interview.
Get the latest from Jon and other industry experts at this
year’s Cell
Therapy Bioprocessing conference, September 15-16, Arlington, VA. Now, SAVE 20% off the standard rate. Register here and use code XB14188BLOG.
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