Monday, September 9, 2013

BioProcess International Poster Preview: TAPBOOST technology: Novel Technology to Enhance the Production of Therapeutic Recombinant Proteins Through Protein Folding System

Leading up to the BioProcess International Event, we'll be highlighting many of the posters you'll be able to find in the hall at the event taking place September 16-19, 2013 in Boston, MA. If you'd like to join us at the event, as a reader of this blog, when you register to join us and mention code BLOG13JP, you'll save 20% off the standard rate!

Poster: TAPBOOST technology: Novel Technology to Enhance the Production of Therapeutic Recombinant Proteins Through Protein Folding System

Presenter: Akinori Hishiya, Boston Strategics Corporation

About: Although protein folding is very important for the production of therapeutic proteins, due to the complicated protein folding system, the technology to specifically promote protein folding of targeted proteins has not been successful yet. TAPBOOST technology is a novel technology which exploits the cellular protein folding system. In TAPBOOST technology, a proprietary protein called “TAPBOOSTER” is expressed together with the therapeutic protein. Selective TAPBOOSTER can be designed to target any kind of protein. The TAPBOOSTER targeted protein is 1) functional, 2) stable, and 3) easy to secrete. All these effects significantly enhance the production of the targeted therapeutic protein. TAPBOOSTER has successfully enhanced the production of many therapeutic recombinant proteins such as Humira® (9 folds), DP12® anti-IL8 antibody (8 folds), Enbrel® (6 folds), and Avastin® (4 folds). Importantly, TAPBOOST technology is very effective especially to proteins with protein folding problem such as IL13Ralpha2-Fc (Fc fusion protein with IL13 receptor alpha2 truncated form). By using TAPBOOST technology, the productivity of IL13Ralpha2-Fc was drastically improved more than 20 folds. The unique mechanism of TAPBOOST technology enables this technology to combine with any other existing technologies to enhance the production of therapeutic protein with synergistic effect.


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