Thursday, August 29, 2013

BioProcess International Poster Preview: High Throughput Viscosity Measurement for Assessing Biologics Formulations

Leading up to the BioProcess International Event, we'll be highlighting many of the posters you'll be able to find in the hall at the event taking place September 16-19, 2013 in Boston, MA. If you'd like to join us at the event, as a reader of this blog, when you register to join us and mention code BLOG13JP, you'll save 20% off the standard rate!

Poster: High Throughput Viscosity Measurement for Assessing Biologics Formulations

Presenter: David Yamane, Freeslate

About:  Biologic formulations are trending toward higher protein concentrations. High concentration formulations can reach viscosities that are not viable for commercialization. Viscosity is consequently becoming a critical consideration during the assessment of potential formulations. Freeslate has developed the CM Protégé Biologic Formulation Assessment System which has a High Throughput Viscosity Measurement Module that enables viscosity measurement of samples using a volume of 100 microlitre and has a throughput of three minutes per measurement. The system can be used to measure both Newtonian and non-Newtonian fluids. The system has been optimized for the measurement of viscous samples (1 cP to 100 cP) across a temperature range from 4 °C to 40 °C. To evaluate the performance of the High Throughput Viscosity Measurement Module on the CM Protégé Bioformulation Assessment System, Bovine Serum Albumin, multiple concentrations of a monoclonal antibody solution measured at multiple temperatures and 24 different monoclonal antibody (mAb) formulations, were tested. Measurements were fast, ~3 minutes/sample, consumed only 100 microlitre of sample and showed excellent reproducibility.

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