Monday, August 19, 2013

BioProcess International Poster Preview: Evaluation of the Cedex Bio and HT Metabolite Analyzers for Cell Culture Process Monitoring

Leading up to the BioProcess International Event, we'll be highlighting many of the posters you'll be able to find in the hall at the event taking place September 16-19, 2013 in Boston, MA. If you'd like to join us at the event, as a reader of this blog, when you register to join us and mention code BLOG13JP, you'll save 20% off the standard rate!  Would you like to submit a poster?  Today is your last day to submit a poster here.

Poster: Evaluation of the Cedex Bio and HT Metabolite Analyzers for Cell Culture Process Monitoring

Presenter: Caroline DiCesare, Genzyme, a Sanofi Company

About the poster: Metabolic intermediates and by-products such as glucose, lactate, glutamine, glutamate, and ammonium are critical cell culture process indicators. The concentrations of these metabolites are often monitored to assess culture performance. This information is frequently used to make decisions during the development and operation of cell culture processes. As such, a metabolite analyzer that is accurate, precise, and reliable is a critical tool in gathering this information. Currently, there are numerous vendors and detection technologies available in the marketplace, including amperometric and photometric based technologies. This poster will present the evaluation results of three commercially available metabolite analyzers: Cedex Bio, Cedex HT and YSI for their accuracy, precision, robustness, ease of use and maintenance. The Cedex platform utilizes a photometric technology whereas the YSI platform is based on amperometric measurements. Our results showed that the Cedex Bio and Cedex HT performed comparably to the YSI 2700 in terms of accuracy and precision for glucose, lactate, glutamine, and glutamate. We will also discuss other pros and cons in terms of additional applications, robustness, ease of use and maintenance of these three analyzers.

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