Thursday, December 13, 2012

Immunogenicity Session Spotlight: A Non-Leaching, Blocking Protein-Free Immunoassay – A New Way to Develop Immunoassays

In today's Immunogenicity for Biotherapeutics session spotlight we look at the revolutionary technique describing the creation of assays free from blocking reagents and the corresponding risk of inappropriate protein results. Though difficult and not yet widespread, this new method can significantly improve the quality of immunoassay results.

The session we feature is  A Non-Leaching, Blocking Protein-Free Immunoassay – A New Way to Develop Immunoassays presented by Yanhe Tong, Large Molecule Bioassays of Teva Pharmaceuticals. For more information on the program, download the agenda. If you'd like to join us March 18-20, 2013 in Baltimore, Maryland, register today and mention code XP1838BLOG and save 15% off the standard rate.

Featured Session: A Non-Leaching, Blocking Protein-Free Immunoassay – A New Way to Develop Immunoassays

Featured Speaker: Yanhe Tong, Large Molecule Bioassays, TEVA Pharmaceuticals

About the session: In traditional immunoassays , coating protein binds to modified polystyrene plate surface by passive absorption. Blocking reagents, commonly needed for immunoassays, are the major source for non-specific binding. Maintaining assays is also difficult since the assay performance may change when incorporating a new lot of blocking reagent. The solution is to not use any blocking reagent in the immunoassay.
  • • Employ covalent binding immunoassay plates to develop a simple, non-leaching, blocking protein-free immunoassay
  • • All immunoassays can be easily developed with a single assay diluent, such as PBST washing buffer
  • • Reduce assay maintenance work and render highly sensitive and consistent assays

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