Thursday, August 2, 2012

Bioassays & Bioanalytical Method Development Session Spotlight: Use of Transfected Cells in Cell-Based ADCC Assays

Transfected cells are a type of cell that can make effector cells from serum far more predictable & reliable. Validated purified receptor surrogates are extremely useful in comparing to results from standard cell-based assays.

This year at the Bioassays and Bioanalytical Method Development Event, Pfizer will be on hand to take a closer look at this.  For more information on this session and the rest of the event, download the agenda.  As a reader of this blog, when you register to join us this October 1-3 in Berkley, California and mention code XP1768BLOG, you'll save 15% off the standard rate!

Featured Session: Use of Transfected Cells in Cell-Based ADCC Assays
Featured Speaker: Poonam Aggarwal, PhD, Senior Principal Scientist, PFIZER
About the session: The biggest challenge you are likely to face in designing robust ADCC assays is the inherent variability across different sources of human blood serum. Yet it is possible for your use of transfected cells to make the effector cells from serum more reliable and predictable. Analyzing the relative comparability of antibodies can shorten your workflow and cut down on some variable and confusing results.
  • • Evaluate ADAs to determine whether they are enhancing ADCCs or not
  • • Pinpoint the Fc gamma receptor binding signal using surface plasmon resonance
  • • Validate your purified receptor surrogates in order to best compare to results from standard cell-based assays

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