Showing posts with label transdermal drug delivery. Show all posts
Showing posts with label transdermal drug delivery. Show all posts

Wednesday, January 27, 2010

DDP 2010: Technology Showcase Spotlight Session - Reaching Beyond Transdermal Delivery Breakthroughs Using TransPharma’s ViaDerm System

Judith Kornfeld
Vice President of Business Development
TransPharma, Inc.

They’re focusing on developing products that are delivered with unique transdermal delivery. It’s the company’s lead product.

The transdermal delivery system’s ease of use points:
-Convenient handling by the patient
-Room temperature storage
-Ready for use
-Easy administration
-Portable
-Picket size product
-No device maintenance

Two patches: printed patches and matrix patches
Current products: ViaDerm hPTH1, ViaDerm-GLP1 (in pipeline)

There are currently 4 clinical trials in the pipeline:
-Positive experience with patients
-Strong clinical data
-scaled up manufacturing lines


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Tuesday, January 26, 2010

DDP 2010: Passport® Transdermal System: Developing Biobetters with a Transdermal Technology for Biological Drugs and Vaccines

Eric Tomlinson, PhD
Chief Executive Officer
Altea Therapeutics

Transdermal, one normally thinks that the drug is delivered by a patch to the skin. Altea has found clinically proven transdermal delivery technology for water-soluble small drugs, biological and vaccines.

Why have a transdermal patch?
-Painless delivery
-High patient compliance
-Improved safety
-Life cycle management
-Expedited regulatory patch

The skin is all dead cells, and they’re interspersed with lipids. The outside layer is the barrier for transdermal delivery other than small transdermal drugs. They work to create subtle channels to introduce the drugs into the skin.

The PassPort® System painlessly creates microscopic channels in the dead outer layer and positions a transdermal patch over the channels. The removal of the outer layer of the skin creates channels to mass transfer drugs. They can be up to 12 square centimeters. The PassPort® has dose reminder features.

Delivery capabilities: 3 Features of a drug: Molecular size (300 kDa), Aqueous solubility (300 mg/mL), Dose achieved per single application.

Patient benefits include high patient compliance with transdermal patches and broad application to water-soluble drugs.


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Thursday, January 21, 2010

2010 DDP Awards: Technology Innovation Nominee: Isis Biopolymer

Technology: IsisIQ™ Patch

Isis Biopolymer, Inc., founded in 2006, is led by a team of experienced scientists and entrepreneurs accomplished at successful development and commercialization of medical devices, materials and systems design. The company has developed a major advance in intelligent non-invasive transdermal drug delivery, the IsisIQ™ Patch. The patch is a fully programmable, single-use, “band-aid-like” active patch that controls and monitors transdermal drug delivery; ensuring safe and accurate administration through the skin using iontophoresis. An innovative solution to the challenges of today’s transdermal drug delivery systems, the IsisIQ™ Patch features a proprietary selective barrier membrane that facilitates the transport or complete cessation of drug molecules through the skin. Drug transport can be modulated for up to three drugs per patch and is fully programmable for customized delivery and monitoring via an integrated wireless communication platform. The unique single electrode design eliminates variability in drug delivery that can occur with changes in the skin due to temperature, moisture and movement; preventing inadvertent or over delivery of drug. The IsisIQ™ Patch is also a biosensor that can detect skin emanations, which may be indications of medical events such as heart attached, shock or diabetic reactions. Breakthroughs in pliable polyester substrate and hydrogels support lower cost development and manufacturing, as well as a more diverse range of delivery of drugs than is currently available. Moving forward, Isis Biopolymer technology will expand the worldwide multi-billion dollar market for transdermal delivery of existing and drugs in development for pain management, oncology, neurology, endocrinology, cardiovascular, CNS disorders, as well as therapies for chronic and acute conditions. Isis Biopolymer has developed not only the technology to revolutionize transdermal drug delivery, but also make it affordable as a result of our materials and manufacturing processes based here in the United States. Isis is focused on providing revolutionary (and cost-effective) transdermal drug delivery and biosensors to improve patient compliance and generate better health care outcomes.

The winners will be announced at an awards ceremony on Tuesday, January 26 at the Drug Delivery Partnerships International Conference.


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