Antibody Engineering Poster: New Tools for High-throughput Engineering, Cloning and Expression of Multispecific Next-generation Antibodies

Leading up to the Antibody Engineering Event, we'll be sharing the posters that will be featured in the Exhibit Hall.  Antibody Engineering & Therapeutics will take place December 8-12, 2013 in Huntington Beach, California.  For more information the program, download the agenda.  If you'd like to join us, as a reader of this blog, when you register to join us and mention code XD13172BLOGJP, you'll save 20% off the standard rate!

Featured Poster: New Tools for High-throughput Engineering, Cloning and Expression of Multispecific Next-generation Antibodies

Featured Presenter: Sebastian Schlicker, Genedata

About the Poster: Next-generation antibodies promise greater clinical efficacy and safety for a variety of severe human diseases. As a consequence, today’s biotechs are faced with generating and testing vastly increased numbers of diverse next-gen antibody molecule formats. A significant bottleneck is the establishment of high-throughput molecular biology and cloning processes required for systematically generating and validating DNA constructs to express the desired molecules. Here, we present a new workflow system for addressing the specific challenges for next-gen antibody molecules produced in large-scale engineering campaigns. The diversity of new molecule formats (e.g. bi- and n-specifics, scFv, tandem-scFv, scFv-Fc, F(ab‘)2, Diabodies, scFv-IgG) and relevant cloning strategies poses workflow challenges that require tailored in silico cloning and automation tools for molecular biology, DNA synthesis, expression and purification sample management, as well as an integrated processing of assay and analytics testing results. We present concrete examples of next-generation antibody workflows using the Genedata Biologics

Do you have new research to share with your industry colleagues? Your poster can be featured in the Antibody Engineering Exhibit hall as well! Find out how here.  The deadline for poster submissions is November 1.

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