Leading up to the Antibody Engineering Event, we'll be sharing the posters that will be featured in the Exhibit Hall. Antibody Engineering & Therapeutics will take place December 8-12, 2013 in Huntington Beach, California. For more information the program, download the agenda. If you'd like to join us, as a reader of this blog, when you register to join us and mention code XD13172BLOGJP, you'll save 20% off the standard rate!Poster: The Probody™ Platform Enables Targeted Therapies Across a Variety of Antibody Formats
Presenter: James West, CytomX Therapeutics, Inc
About the Poster: Probodies enhance the specificity of antibody therapeutics through local activation
at sites of disease where specific proteases are upregulated in activity, for example, in the proteolytically active tumor microenvironment. This local activity can be harnessed to activate a Probody, a recombinant fusion protein in which a masking peptide that blocks the antigen-combining site is linked through a substrate-containing peptide to a functional antibody. Once the substrate linker is cleaved, the masking peptide dissociates, releasing an active form of the antibody. We have shown that the Probody concept is applicable to multiple therapeutic antibody formats, resulting in improved therapeutic index, in a variety of preclinical models.
Do you have new research to share with your industry colleagues? Your poster can be featured in the Antibody Engineering Exhibit hall as well! Find out how here. The deadline for poster submissions is November 1.
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