BioProcess International will take place October 8-12 in Providence, Rhode Island. For more information on this program featuring over 180+ speakers, download the agenda here. Would you like to join us? Register today.
Featured Session: Exploiting Online Refractometry for Improved Ultrafiltration Development and Manufacturing Engineering Operation Control
Featured Speaker: Nickolas Brings, MBA, Process Engineer, Global Engineering and Facilities, Biogen Idec
About the Session: Accurate targeting of high protein concentration Drug Product formulations has become a challenge within biological manufacturing arenas via traditional absorbance methods and process control techniques. The work presented here will demonstrate the application of inline refractometry to provide real-time concentration measurements for enhanced ultrafiltration process monitoring and control. Data will be presented from pilot and clinical manufacturing systems. In summary, inline probes demonstrated >96% concentration accuracy up to 150g/L. Additional applications for inline refractometry will be discussed for Biologics processing.
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